Copper Peptides Act as a Biological Skin Care Ingredient by Thickening Skin and Improving Elasticity and Fibroblast Production.

Copper Peptides in the Restorative Secretion of Snails Help to Enhance Skin Healing and Minimize Post Burn Scars.

Improperly healed injuries feature incorrect or abnormal deposition of collagen and defective skin cell layering.

A class of compounds called "copper peptides" has been researched in the laboratory for their ability to reorganize the process of injury repairing by diminishing scar formation and improving skin remodeling and they are present naturally in the complex biological ingredient that is essential in our products.

For years, the only source of this ingredient has been those synthezised in a laboratory from soy proteins after the innovative work of Dr. Loren Pickart. Dr. Pickart is a scientist who postulated this revolutionary theory that copper peptides have skin remodeling properties, stimulate and are integral to the process of skin renewal (www.skinbiology.com). We could now state that their participation in the healing secretions of snails legitimizes their important biological functions.

What exactly are copper peptides and how can they modify the biological response to injuries? Generally speaking, peptides are tiny fragments of proteins. (And the proteins are the one of the key building blocks of most living tissues, the other are complex carbohydrates or sugar chains and DNA.) Certain kinds of peptides have a huge affinity for copper, to which they bind very tightly. The final compound consisting of a peptide and a copper atom has become known as a copper peptide.

The secretions collected from snails provide the only natural source of these molecules as they have glycosaminoglycans (GAGs) that tightly bind divalent copper cations Cu +2 and peptides, copper peptides.

Dr Pickart found copper peptides while doing experiments that intended to reverse certain effects of aging in animals. Since then, GHK-Cu and some other copper-peptides, have been found to accelerate the regeneration and healing process of many types of mammalian tissues.

Studies, at several universities and research institutes, have found that copper-peptides:

- Speed up injury healing (humans, mice, rats, guinea pigs, pigs, dogs)

- Enhance skin re-epithelialization (humans, animals)

- Improve skin graft transplant success (pigs)

- Improve hair transplant success (humans)

- GHK analogs with fatty residue analogs increase hair follicle size, stimulate hair growth and reduce hair loss (humans, mice, rats). Increases hair growth after chemotherapy (rats)

- Counter aging effects on skin (humans)

- Thickens skin, shrinks small and large wrinkles, reduces blotchiness and blemishes, improves elasticity, and increases keratinocyte and fibroblast production, thickens the subcutaneous fat layer

- Activates bone repairing (guinea pigs, pigs, rabbits)

- Cure stomach ulcers (rats)

- Cure injured intestinal linings (humans, rats)

- Block oxidative damage in tissues.

- Restore normal function in livers affected by toxins (rats)

- Numerous anti-inflammatory actions (reduces liberation of oxidizing iron, TNF-alpha, TGF-beta-1, IL-1)

Many substances can have a positive effect on wound repairing. A distinctive feature of copper peptides is that they diminish scar tissue generation while promoting normal skin remodeling. In other words, they help restore the damaged area to its original look.

The process of copper peptide action is somewhat complex. Copper bound to aminoacids induces the degradation of "extra-large" collagen aggregates located in scars and induces the creation of smaller more regular collagen found in normal skin. It also induces the synthesis of elastin, proteoglycans, glycosaminoglycans, and other components of the skin matrix. Other important effects of Copper Peptides include the ability to manage the growth rate and distribution of several types of cells; significant anti-inflammatory action; and the ability to avoid the liberation of oxidation-promoting iron into the tissues. The final result is a faster, better and "cleaner" resolution of wounds.

Can copper peptides be useful for regular skin safeguarding and renewal?

While the production and breakdown of collagen, elastin, and water-holding GAGs exists in a continuous balance in young healthy skin, after age 25 the skin's synthesis of collagen, elastin, and the water-holding GAGs is slowed down while the rate of breakdown of these factors is raised and starts wrinkle formation and loss of elasticity. The problem becomes more and more serious with passing years. The good news is there are now synthetic (synthetic copper peptides) and natural substances (snail glycoconjugates that also contain copper peptides as part of a intricate biological activator of skin healing and remodeling) that can go against this process.

The available evidence showed the following possible skin benefits of copper peptides:

Many existing skin care treatments are based on the concept of removing the outermost or even deeper layers of skin. The resulting healing process stimulates skin remodeling, resulting in smoother, younger looking skin. Since copper peptides improve healing and optimize skin remodeling, they can increase the effect of treatments based on several kinds of controlled skin damage. In particular, copper peptides can be useful after several kinds of laser resurfacing, dermabrasion, and chemical peels.

Copper peptides are useful against several kinds of skin irritation, mainly thanks to their anti-inflammatory effects. Skin irritation, even if there are no open injuries, greatly accelerates skin aging by stimulating the formation of free radicals and other toxic byproducts. Some typical skin rejuvenation treatments, like tretinoin (Retin A, Renova) and alpha hydroxy acids can cause irritation. If during treatment you suffer skin irritation for a prolonged period of time, your skin will likely end up in worse condition than when you started. In many cases, copper peptides can diminish or avoid the irritation and help improve treatment benefits.

It is always wiser to avoid the damage than to fix it later. To a high degree, skin aging is induced by the accumulation of small day-to-day damage from sun, acne, wind, detergents, abrasions and so forth. As these tiny lesions heal, they form microscopic blemishes, which eventually accumulate to become visible signs of aging. While it remains to be further investigated, it appears that copper peptides can help diminish the damage from daily aggressions to the skin. For instance, one study found that copper peptides helped recover skin integrity after exposure to SLS, a current detergent used in many shampoos, cleansers, and dishwashing/laundry products.

Can copper peptides reverse wrinkles and other signs of aging in healthy skin?

Yes, because copper peptides stimulate the degradation of abnormally large cross-linked collagen (the one present in scars and, to a lesser degree, in wrinkles). They also stimulate the synthesis of "regular" collagen found in normal skin. In one small study, copper peptides promoted collagen production in healthy skin. In fact, in that study, copper peptides induced a stronger stimulation of collagen synthesis than tretinoin (Retin A, Renova) or ascorbate (vitamin C). While clinical studies have shown the positive effects on photo-aged skin from the daily application for 4 to 8 weeks of cosmetic preparations with the snail secretions, which contain copper peptides and complex glycoconjugates.

While standard use of synthetic copper peptides promotes collagen synthesis and has antioxidant effect (by stimulating the antioxidant enzyme superoxide dismutase), exaggerated use of synthetic copper peptides extracted from soy proteins can have an opposite effect by raising the levels of free copper. Free copper leads to free radical damage and collagen breakdown, inducing accelerated skin aging. These troubles do not seem to appear among the majority of copper peptide users. However, there are anecdotal reports showing that such side-effects might appear with overuse or, rarely, even normal use in certain people. Ideally, a sufficiently extensive study is required to better measure these risks.

Finally, copper peptides found as part of the intricate glycoconjugates secreted by land snails are a safe and effective skin treatment. Their ability to optimize the repairing of several types of skin lesions is well established. And the snail secretions decelerate the development of the signs of skin aging by limiting the effects of daily wear and tear. Also, the snail secretions have an effect on skin renewal due to the presence in them of enzymes that degrade denatured proteins into their amino-acid components and trigger an harmonic rebuilding and remodeling of the skin tissues.

What makes the copper peptides in BIOSKINCARE efficient and reliable?

A natural cosmetic product, not a drug or pharmaceutical product.

BIOSKINCARET is fabricated with the natural secretions from a land snail (Helix Aspersa Muller), the same they produce to quickly restore their own skin and shell when damaged. It is a viscose liquid that is converted into an odorless white cream.

Analysis of the mucin has shown that it contains activators of skin growth factors, natural anti-inflammatory and immune modulating proteins, antimicrobial peptides, glycoproteins, glycosaminoglycans that tightly bind divalent copper cations Cu +2, and acharan sulfate glycosaminoglycan (GAGs) as a protein-free polysaccharide.

Unlike irritating chemicals and physical processing often used to create protein supplements, which unfortunately denatures (destroys) the natural configuration of proteins yielding something that is not completely absorbed and utilized by the human body. The proteic secretions of the snail are taken as they are originally to make them into our product, without any process that may denature them and on the contrary their bio-availabity for living cells is completely preserved.

Double blind studies comparing placebo to the active product on one side of the face compared to the other using objective techniques to measure wrinkle depth have demonstrated improvement in this parameter as well as skin smoothness, suppleness, and decrease of hiperpigmentation in more than 80% of subjects investigated. Most people have seen results in as little as two weeks when they have used BIOSKINCARET cream twice a day every day.

Topical application of BIOSKINCARET is also a strong message that signals to your body that it is being taking care of in a balanced and proper manner, with all the ingredients that help it quicken the natural skin healing process.

Use of the product night and day for a period of 8 weeks yields: Decrease in wrinkles depth, Increase in collagen and elastin from within the submerged layers of the skin, giving skin firmness, Improvement of the water retention ability of healthy skin, reducing sagging and fragility, Decrease of age spots, dark pigmentation, hyperpigmentation, melasma, Relief of topic dermatitis, Return of the natural skin color of those affected by hiperpigmentation in people of all skin colors, including African, Asian & Latin.

BIOSKINCARET helps your skin rebuild and moisturize itself! There is nothing like it! It has been used on age lines, insect bites/stings, skin ulcers, acne, chilblains, boils, age spots, athlete's foot, diabetic sores, abrasions, skin allergies, infected nails, diaper rash and stretch marks and other skin problems and conditions. It is just excellent. Wounds heal with minimal scar formation. Try BIOSKINCARET and help your skin revitalize naturally!

BIOSKINCARET has a double effect: (1) Degrades debris, damage, abnormal and necrotic tissues & cleanses the skin as it helps to eliminate all damaged structures into their amino-acid and other components by the action of enzymes. (2) Favors tissue restoration.

It leaves your skin smooth, refreshed, soft and using it over a period of time it shrinks contractures and eliminates keloid, hypertrophic and all types of scars and blemishes: acne, actinic keratosis lesions, scars, cuts, scrapes, roughness, the effects on the skin of radiotherapy for cancer, eczema, dryness, keratosis bumps, dermatitis, razor nicks and burns, blisters, and the list can go on and on... It clears and enhances the complexion.

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